Vly News - Professional news Platform

Researchers at the University of Wisconsin-Madison have described the way enzymes and proteins interact to maintain protective coverings, called telomeres, at the ends of chromosomes, a new insight into how human cells maintain the integrity of their DNA through repeated cell division. . DNA replication is critical to sustaining life as we know it, but much of the complexity of the process — how myriad biomolecules get to where they need to be and interact through a series of intricately orchestrated steps — remains a mystery. From left, Qixiang He, Ci Ji Lim, Xiuhua Lin. “The mechanism behind how this enzyme, called Polα-primase, works has been elusive for decades,” said Ci Ji Lim, assistant professor of biochemistry and principal investigator on a new study on DNA replication published recently in Nature. “Our study provides a major breakthrough in understanding DNA synthesis at the ends of chromosomes, and generates new hypotheses about how Polα-primase – the main cog in the DNA r

A set of genes that promote the sensation of sweetness are also important for protein management during fly development, according to a new study by Eugenia Piddini of the University of Bristol, UK, and colleagues, published July 21. st in open access journal PLOS Biology . These findings broaden the understanding of key processes in successful development, and demonstrate a link between taste-related genes and impaired protein aggregation. Protein homeostasis, or proteostasis, is a set of processes that maintain cellular proteins in a functional state, and remove damaged proteins that cannot be repaired. Ribosomes are multi-protein molecular machinery that synthesizes proteins, and mutations in the genes encoding ribosomal proteins not only impair protein synthesis but also impair proteostasis, leading to chronic proteotoxic stress. That stress, in turn, has a number of cellular consequences and results in delayed development and other irregularities. To better understand the distu