Anti-bacterial linker: How communication between lysosomes and mitochondria controls Salmonella growth in macrophages - Azi News
Macrophages are key cells of our innate immune response. By filling up almost all the tissues in our body, these cells have an important role in keeping our organs in a healthy state, as they are constantly removing dead cells or eliminating microbes invading tissues. As cells that specialize in eating and devouring, macrophages are very well adapted to take in, digest, and destroy foreign materials. However, certain microorganisms and bacteria such as Salmonella have developed strategies to protect themselves from ingesting macrophages, causing severe typhoid infection and inflammation. Scientists from the MPI of Immunobiology and Epigenetics in Freiburg now report in their latest study published in the scientific journal Natural Metabolism how inter-organelle crosstalk between phago-lysosomes and mitochondria limits the growth of these bacteria in macrophages. Signals from digestive cell organelles The interior of a macrophage, like most other cells, is divided into different com