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Super-resolution microscopy allows fluorescence images of cells, organelles and molecular complexes to be obtained with unprecedented spatial resolution. However, this resolution is not sufficient to resolve proteins as small as a few nanometers and their interactions with other molecules or the architecture of protein complexes. This prevents, for example, the study of the molecular interactions of neurons in learning and memory processes. Overcome dynamic resolution limit Developed by the research groups of Prof Markus Sauer (Rudolf Virchow Center and Biocenter) and Dr Gerti Beliu (Rudolf Virchow Center) at the University of Würzburg, the new photoswitching fingerprint analysis enables optical imaging of dynamic interactions with other molecules in cells. “To date, no method has reliably enabled structural optical resolution in cells in the sub-10 nm range. By elucidating the underlying cause of this barrier, we have succeeded for the first time, in combination with a new dir...

Super-resolution microscopy allows fluorescence images of cells, organelles and molecular complexes to be obtained with unprecedented spatial resolution. However, this resolution is not sufficient to resolve proteins as small as a few nanometers and their interactions with other molecules or the architecture of protein complexes. This prevents, for example, the study of the molecular interactions of neurons in learning and memory processes. Overcome dynamic resolution limit Developed by the research groups of Prof Markus Sauer (Rudolf Virchow Center and Biocenter) and Dr Gerti Beliu (Rudolf Virchow Center) at the University of Würzburg, the new photoswitching fingerprint analysis enables optical imaging of dynamic interactions with other molecules in cells. “Until now, there was no reliable method of enabling structural optical resolution in cells in the sub-10 nm range. By elucidating the underlying cause of this barrier, we have succeeded for the first time, in combination with a...

What do building a pyramid, going to the moon, pedaling a two-person canoe, or dancing the waltz have in common? All of these actions are the result of a common goal between many partners and lead to a sense of shared obligation, known as “mutual commitment”. This ability to cooperate is universal in humans and certain animal species, such as the great apes. However, humans seem to have a unique predisposition and strong desire for social interaction that may be one component of the emergence of language, according to the study authors. How do our social interactions differ from other species? And why? To answer this question, an international team analyzed the interactions of 31 children between the ages of 2 and 4 in four preschools in the United States (10 hours per child). There are only a few quantitative analyzes of the spontaneous social interactions of children aged 2 and 4 years when interacting with peers, even though this age is a critical age for the develop...

A study of the herpes virus infecting chickens offers new insight into the potentially problematic interactions between vaccines made from live viruses and viruses that are meant to be thwarted. Reported in the journal Virulence, the study offers direct evidence that vaccines and viruses can infect the same cells in live animals and share the molecular tools that allow the virus to infect other animals – in this case, chickens. The study focused on Marek’s disease, a viral infection that is spread when a chicken inhales flakes of dead skin or feather tissue from an infected chicken. “We’ve been trying to understand how the virus spreads from one host to another,” said University of Illinois Urbana-Champaign pathobiology professor Keith Jarosinski, who led the study. “Not only did we do it for the benefit of chickens in the poultry industry, but also because of a very similar mechanism used by the virus that causes chickenpox, where it enters through the re...