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Poisonous nut tree Strychnos nux-vomica. Credit: Danny Kessler, Max Planck Institute for Chemical Ecology Researchers from Jena show how poisonous nut trees form strychnine. A team of scientists from the Max Planck Institute for Chemical Ecology in Jena revealed a complete biosynthetic pathway for strychnine formation in plant species. Strychnos nux-vomica (poison nut). After identifying all the genes involved in the biosynthesis of strychnine and other metabolites, the researchers expressed them in a plant model. Nicotiana benthamiana . This suggests that this highly complex and pharmacologically important molecule can be synthesized using “metabolic engineering” methods. Strychnine is something that many people know from crime reports, novels, or movies. For example, Agatha Christie had several of her victims die from strychnine poisoning. In his first novel “The Mysterious Affair at Style,” he described what is perhaps the most famous fictional murder case involving...

Researchers from Jena show how poisonous nut trees form strychnine A research team at the Max Planck Institute for Chemical Ecology in Jena revealed a complete biosynthetic pathway for strychnine formation in the plant species Strychnos nux-vomica (poison pea). The researchers identified all the genes involved in the biosynthesis of strychnine and other metabolites and expressed them in the plant model Nicotiana benthamiana. This allowed them to demonstrate that this highly complex and pharmacologically important molecule could be synthesized using “metabolic engineering” methods. Strychnos nux-vomica “> Poisonous nut tree Strychnos nux-vomica © Danny Kessler, Max Planck Institute for Chemical Ecology Poisonous nut tree Strychnos nux-vomica © Danny Kessler, Max Planck Institute for Chemical Ecology Many of us know strychnine from crime reports, novels or movies. Agatha Christie has had several of her victims die from strychnine poisoning. He described w...