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“These results help us refine a systematic network map that can serve as an instruction manual on how human immune cells function and how we can engineer them to our advantage,” said Alex Marson MD, PhD, director of the Gladstone-UCSF Institute of Genomic Immunology and senior author of the new study, published in Natural Genetics . The study, which was carried out in collaboration with Jonathan Pritchard PhD, professor of genetics and biology at Stanford School of Medicine, is also important for better understanding how variations in a person’s genes are related to the risk of autoimmune diseases. Immunity Insights from CRISPR Researchers know that when the immune system’s T cells—white blood cells that can fight infection and cancer—become active, the levels of thousands of proteins in the cells change. They also know that many proteins are interconnected so that a change in the level of one protein can cause a change in the level of another. Scientists repres...

Using new technology to study thousands of genes simultaneously in immune cells, researchers at the Gladstone Institutes, UC San Francisco (UCSF), and the Stanford School of Medicine have created the most detailed map of how complex networks of genes function together. New insights into how these genes relate to one another shed light on the basic drivers of immune cell function and immune disease. “These results help us refine a systematic network map that can serve as an instruction manual for how human immune cells function and how we can engineer them to our advantage,” says Alex Marson, MD, PhD, director of the Gladstone-UCSF Institute of Genomic Immunology and senior author. from the new study, published in Nature Genetics. The study, carried out in collaboration with Jonathan Pritchard, PhD, professor of genetics and biology at Stanford School of Medicine, is also important for better understanding how a person’s gene variation is linked to the risk of autoimmu...

Human immunodeficiency virus 1, more commonly known as HIV-1, is known for its remarkable ability to evade the immune system. Scientists at Scripps Research and collaborators have now discovered how our innate immune system – the body’s first line of defense against foreign invaders – detects HIV-1, even when the virus is present in very small amounts. His findings, published on July 8, 2022, in molecular cell , revealing a two-step molecular strategy that jolts the innate immune response into action upon exposure to HIV-1. These discoveries could impact the development of drugs for HIV treatments and vaccines, as well as shape our understanding of how the innate immune response is involved in other areas – including neurodegenerative disorders such as Alzheimer’s. “This study illustrates how the immune system can recognize a very cryptic virus, and then activate a downstream cascade that leads to immunological activation,” said Sumit Chanda, PhD, professor in ...