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Victoria’s father Jack Lord Gamble was “always a little wobbly”. The 37-year-old is simply someone who “gets into a vibe from time to time”. However, as his friends worried about his deteriorating condition, the Melbourne dad knew something more serious was at play. For more Health & Wellness related news and videos, check out Health & Wellness >> Then came the news that turned his world upside down – Jack had Parkinson’s disease. “It’s difficult, definitely harder than I realized,” he told 7NEWS.com.au. While coming to terms with life-changing conditions takes time, Jack hopes his experience can help others realize they are not alone and dispel common misconceptions. Melbourne father Jack Lord Gamble was diagnosed with Parkinson’s disease at the age of 33. Credit: provided Around 38 Australians are diagnosed with Parkinson’s every day. In 2018, Jack found himself among those statistics. Parkinson’s is not common in people under 50, with only 10 to 20 percent of peo

Human immunodeficiency virus 1, more commonly known as HIV-1, is known for its remarkable ability to evade the immune system. Scientists at Scripps Research and collaborators have now discovered how our innate immune system – the body’s first line of defense against foreign invaders – detects HIV-1, even when the virus is present in very small amounts. His findings, published on July 8, 2022, in molecular cell , revealing a two-step molecular strategy that jolts the innate immune response into action upon exposure to HIV-1. These discoveries could impact the development of drugs for HIV treatments and vaccines, as well as shape our understanding of how the innate immune response is involved in other areas – including neurodegenerative disorders such as Alzheimer’s. “This study illustrates how the immune system can recognize a very cryptic virus, and then activate a downstream cascade that leads to immunological activation,” said Sumit Chanda, PhD, professor in the Department of Immun

Immunotherapy, such as immune checkpoint inhibitors, has changed the treatment of advanced cancers. Unlike chemotherapy which kills cancer cells, these drugs help the immune system to find and destroy the cancer cells themselves. Unfortunately, only a subset of patients respond to immune checkpoint inhibitors in the long term; and these treatments can be expensive and with side effects. Researchers have developed a two-step approach using whole-exome sequencing to target genes and pathways that predict whether cancer patients will respond to immunotherapy. Studies published in Nature Communication and conducted by researchers at New York University, Weill Cornell Medicine, and the New York Genome Center, illustrates how using whole-exome sequencing can better predict treatment response than current laboratory tests. “Can we better predict who will benefit from immunotherapy? Scientists have developed a variety of biomarkers that help anticipate immunotherapy treatment responses, b

AUSTIN, Texas – For more affordable and sustainable drug options than we have today, the drugs we use to treat high blood pressure, pain or memory loss may someday come from engineered bacteria, cultured in vats like yogurt. And thanks to a new bacterial tool developed by scientists at The University of Texas at Austin, the process of increasing drug-making in bacterial cells may be happening more quickly than we think. For decades, researchers have been looking for ways to make drug manufacturing more affordable and sustainable than current pharmaceutical manufacturing processes, many of which rely on plants or petroleum. Using bacteria has been suggested as a good organic alternative, but detecting and optimizing the production of therapeutic molecules is difficult and time-consuming, taking months. In a new paper this week in Nature Chemical Biology, the UT Austin team introduces a biosensor system, derived from the bacterium E. coli, that can be adapted to detect all types of th

Opioids are the gold standard for the treatment of chronic and acute pain; however, their use can cause significant gastrointestinal side effects, including nausea, vomiting, and constipation. The reasons behind these side effects are not well understood. A new study in American Journal of Pathology published by Elsevier, is the first report on how opioids such as morphine cause stomach inflammation and how this condition can be reversed through treatment with proton pump inhibitor drugs such as omeprazole, an over-the-counter drug commonly used to reduce stomach acid. Due to the lack of better alternatives, morphine is still considered one of the best pain management drugs despite its association with significant comorbidities. Several research groups, including our own, have worked for a long time to understand this phenomenon and to decipher the mechanisms underlying the gastrointestinal side effects of morphine.” Sabita Roy, PhD, Principal Investigator, Department of Surgery, M