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Source/Disclosure Disclosure: Clauw’s report testifies in a state lawsuit against opioid manufacturers for their role in the opioid overdose crisis. ADD TOPIC TO EMAIL ALERTS Receive emails when new articles are posted on Please provide your email address to receive emails when new articles are posted on . ” data-action=”subscribe”> Subscribe We were unable to process your request. Please try again later. If you continue to experience this problem, please contact customerservice@slakinc.com. Back to Healio Central sensitization may be an important underlying factor complicating the treatment of chronic pain and opioid use disorders, write the researchers in PAIN Report. Orman Trent Hall, DO an osteopathic physician and addiction psychiatrist at Ohio State University’s Wexner Medical Center, and colleagues...

Opioids are the gold standard for the treatment of chronic and acute pain; however, their use can cause significant gastrointestinal side effects, including nausea, vomiting, and constipation. The reasons behind these side effects are not well understood. A new study in American Journal of Pathology published by Elsevier, is the first report on how opioids such as morphine cause stomach inflammation and how this condition can be reversed through treatment with proton pump inhibitor drugs such as omeprazole, an over-the-counter drug commonly used to reduce stomach acid. Due to the lack of better alternatives, morphine is still considered one of the best pain management drugs despite its association with significant comorbidities. Several research groups, including our own, have worked for a long time to understand this phenomenon and to decipher the mechanisms underlying the gastrointestinal side effects of morphine.” Sabita Roy, PhD, Principal Investigator, Department of Surge...