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Using innovative microscopy methods, scientists at The Picower Institute for Learning and Memory at MIT observed how nascent neurons struggle to reach their rightful places in a sophisticated human brain network model of Rett syndrome, yielding new insights into how developmental deficits are observed in humans. patient’s brain. with devastating interference may arise. Rett syndrome, which is characterized by symptoms including severe intellectual disability and impaired social behavior, is caused by a mutation in the MECP2 gene. To gain new insight into how mutations affect the early stages of human brain development, researchers in the lab of Mriganka Sur, Newton Professor of Neuroscience in MIT’s Department of Brain and Cognitive Sciences, grew 3D cell cultures called cerebral organoids, or miniature brains, using cells from humans. -people with the MECP2 mutation and compared them with identical cultures without the mutation. Then a team led by postdoc Murat Yildirim ...

Credit: Pixabay/CC0 Public Domain Using innovative microscopy methods, scientists at The Picower Institute for Learning and Memory at MIT observed how nascent neurons struggle to reach their rightful places in a sophisticated human brain network model of Rett syndrome, yielding new insights into how developmental deficits are observed in humans. patient’s brain. with devastating interference may arise. Rett syndrome, which is characterized by symptoms including severe intellectual disability and impaired social behavior, is caused by a mutation in the MECP2 gene. To gain new insight into how mutations affect the early stages of human brain development, researchers in the lab of Mriganka Sur, Newton Professor of Neuroscience in MIT’s Department of Brain and Cognitive Sciences, grew 3D cell cultures called cerebral organoids, or miniature brains, using cells from humans. -people with the M...

Researchers at ORNL used TRITON to simulate flooding in Houston, Texas, and surrounding areas caused by Hurricane Harvey in 2017. Light purples represent shallower water, and dark purples represent deeper water. Credit: Sudershan Gangrade/ORNL A team of researchers from the Department of Energy’s Oak Ridge National Laboratory and Tennessee Technological University has created a 2D open-source flood inundation model designed for multi-architecture computing systems. The Two-dimensional Runoff Inundation Toolkit for Operational Needs, or TRITON, can use multiple graphics processing units, or GPUs, to model floods more quickly and accurately than existing tools. Flood modeling is an important part of emergency preparedness and response. However, models must be fast and accurate—returning simulation results in minutes—to be a useful tool for decision making and planning. The higher the resolution of the model, the more computing pow...

Every biological process is highly dependent on temperature. This applies to the very small, the very large, and every scale in between, from molecules to ecosystems and in every environment. A general theory explaining how life depends on temperature is lacking — until recently. In a paper published in the Proceedings of the National Academy of Sciences, researchers led by Jose Ignacio Arroyo, a Santa Fe Institute Postdoctoral Fellow, introduce a simple framework that strictly predicts how temperature affects living things, at all scales. “This is very basic,” says SFI External Professor Pablo Marquet, an ecologist at the Pontifica Universidad Catolica de Chile, in Santiago. Marquet, Ph.D. thesis advisor, is also working on the model. “You can apply this to almost any process that is affected by temperature. We hope this will be an important contribution.” Marquet noted that such a theory could help researchers make accurate predictions in a variety of areas, including biologica...

A new general theory for temperature dependence in biology developed by the Santa Fe Institute could help researchers make accurate predictions in a variety of fields, including biological responses to climate change, the spread of infectious diseases, and food production. Credits: Dall-E / Katie Mast Every biological process is highly dependent on temperature. This applies to the very small, the very large, and every scale in between, from molecules to ecosystems and in every environment. A general theory explaining how life depends on temperature is lacking—until now. In a paper published in Proceedings of the National Academy of Sciences, researchers led by Jose Ignacio Arroyo, a Santa Fe Institute Postdoctoral Fellow, introduced a simple framework that rigorously predicts how temperature affects living things, at all scales. “It’s very basic,” said SFI External Professor Pablo Marquet, an ecologist at the Pontific...

Australian model Amber Luke has shared more dramatic before and after photos of her wild $250,000 transformation into ‘Dragon Girl’. Amber was once a fresh-faced blonde with no facial tattoos before spending big bucks on extreme ink and body modifications. She posted early social media photos of herself with almost no makeup on her skin and her platinum locks styled in a subtle blow-dry. Australian model Amber Luke has shared more dramatic before and after photos of her wild $250,000 transformation into ‘Dragon Girl’. Left, before. Right after In the selfie she wears a button-down short-sleeved leather jacket and a striped top underneath. This is far from how it looks today. In addition to her elaborate collection of tattoos, Amber has undergone a number of procedures to transform herself, including injecting blue ink into her eyeballs and splitting her tongue in half. She often poses in bondage-style bikinis and underwear to show off her eye-open...

A new three-dimensional model of the fluid stored deep within the Earth’s crust along the Cascadia Subduction Zone provides new insights into how the accumulation and release of such fluid can affect seismic activity in the region. The liquid collects near but does not penetrate the thickened section of crust known as Siletzia lying beneath much of western Oregon and Washington. The pressure associated with this fluid could be a factor in the seismic phenomenon known as episodic tremor and slip, or ETS, said Gary Egbert, an electromagnetic geophysicist at Oregon State’s College of Earth, Ocean, and Atmospheric Sciences and lead author of the new paper. detail the findings. Episodic tremors and slips are fault behaviors that include localized non-volcanic vibrations and slow slip events that may occur over hours or days. It occurs throughout the Cascadia Subduction Zone, from northern California to British Columbia, but is less frequent and intense under the Siletzia centr...

The Y is a few thousand dollars more expensive than its sedan sibling (prices seem to have bounced a lot; the Y launched at $68,900 and jumped $3400 a week later). The listed price for our base model version is $72,300, with silver metallic paintwork, 20-inch “Induction” wheels (replacing the 19s that come as standard), premium black and white interior, plus ordering and shipping costs add $7625, and rego etc counts in a few thousand more (gives a total drive-away price in NSW of $84,160). The springy, plastic seating at Y isn’t to everyone’s taste. Inside, the standard edition panoramic glass roof makes for a lighter, brighter and more airy interior (this adds a bit of headroom). I’m not sure about the bright white seating material in our car. It’s soft and supple and very, very plastic. Most everything else impressed, however. The minimalistic, almost buttonless interior generally works well, with discreet and smart multifunction “thumb...

People’s attitudes towards vaccines can now be detected from their social media posts with a smart AI model, developed by researchers at the University of Warwick. An AI-based model can analyze social media posts and determine the author’s attitude towards vaccines, by being ‘trained’ to recognize that attitude from a small number of sample tweets. As a simple example, if a post contains mention of distrust of health care institutions, fear of needles, or something related to a known conspiracy theory, the model can recognize that the person who wrote it may have negative feelings about vaccinations. The research, funded by UK Research and Innovation (UKRI), will be presented today (12 July) at the North American Association of Computational Linguistics Annual Conference 2022. It is led by Professor Yulan He from the University’s Department of Computer Science, supported by a 5-year Turing AI Fellowship funded by the EPSRC. Professor He and his colleagues a...

It takes a lot of time and money to diagnose Alzheimer’s disease. After running a lengthy face-to-face neuropsychological exam, the doctor must copy, review, and analyze each response in detail. But researchers at Boston University have developed a new tool that could automate the process and eventually allow it to move online. Their machine learning-powered computational model can detect cognitive impairment from audio recordings of neuropsychological-tests; no in-person appointment required. Their findings were published in Alzheimer’s & Dementia: Journal of the Alzheimer’s Association . “This approach brings us one step closer to early intervention,” said Ioannis Paschalidis, co-author of the paper and BU College of Engineering Distinguished Professor of Engineering. He said faster early detection of Alzheimer’s could prompt larger clinical trials that focus on individuals in the early stages of the disease and potentially enable clinica...

In a world full of opposing views, let’s draw attention to something we all agree on: if I show you my pen, and then hide it behind me, my pen is still there – even though you can’t see it anymore. We can all agree that it’s still there, and probably the same shape and color as before it went behind me. This is just common sense. This common sense law of the physical world is universally understood by humans. Even a two month old baby shares this understanding. But scientists are still confused about some aspects of how we reach this fundamental understanding. And we haven’t built a computer that can compete with babies’ normally developing common sense abilities. New research by Luis Piloto and his colleagues at Princeton University – which I reviewed for an article in Nature Human Behavior – takes steps to fill this gap. Researchers created a deep learning artificial intelligence (AI) system that gains an understanding of some common sense laws of t...

Model struggling with severe acne reveals ‘secret’ weapon she used to achieve ‘glassy smooth skin’ in just six months: ‘You can thank me later’ Model Jordan Simek has shared her skin-changing skincare routine Aussie youth struggles with acne and redness for years She started using Secret Skin Care and saw her skin change ‘Your skin will thank me later, I promise,’ he said next to a snap of his face By Laura House For The Australian Daily Mail Published: 00:29 EDT, 7 July 2022 | Updated: 04:42 EDT, 7 July 2022 An Australian model has shared a ‘secret’ weapon that has cleared her acne and redness and left her with ‘glassy smooth’ skin in just six months. Jordan Simek, from Sydney, has finally revealed that he’s been using Secret Skin Care after ‘gatekeeping’ his routine for a while – and the results speak for themselves. Sta...