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Using only skin cells, the Israeli lab makes synthetic mouse embryos with a heartbeat

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An Israeli laboratory has grown synthetic mouse embryos with a beating brain and heart — in an egg-free sperm-free procedure that uses stem cells taken from the skin. The breakthrough, published Monday in the peer-reviewed journal Cell, is the first time advanced embryos of any species have been made from stem cells alone, said cell biologist Prof. Jacob Hanna of the Weizmann Institute of Science told The Times of Israel. . Hanna, who led the research, said that previous efforts have only led to blastocysts, meaning structures formed early in mammalian development. Blastocysts have a fraction of the millions of more cells present in their embryos. “Excellent,” he commented. “No sperm, no eggs and no uterus, but we managed to get embryos formed from stem cells alone for up to eight days – a third of the gestational age of mice – with beating hearts.” He said the research could one day be used to grow artificial human embryo-like structures to produce cells for futuristic medical sol

Advanced imaging finds entangled neuronal migration in lab model of Rett . syndrome

Using innovative microscopy methods, scientists at The Picower Institute for Learning and Memory at MIT observed how nascent neurons struggle to reach their rightful places in a sophisticated human brain network model of Rett syndrome, yielding new insights into how developmental deficits are observed in humans. patient’s brain. with devastating interference may arise. Rett syndrome, which is characterized by symptoms including severe intellectual disability and impaired social behavior, is caused by a mutation in the MECP2 gene. To gain new insight into how mutations affect the early stages of human brain development, researchers in the lab of Mriganka Sur, Newton Professor of Neuroscience in MIT’s Department of Brain and Cognitive Sciences, grew 3D cell cultures called cerebral organoids, or miniature brains, using cells from humans. -people with the MECP2 mutation and compared them with identical cultures without the mutation. Then a team led by postdoc Murat Yildirim examined th

Advanced imaging reveals mired neuronal migration in lab model of Rett . syndrome

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Credit: Pixabay/CC0 Public Domain Using innovative microscopy methods, scientists at The Picower Institute for Learning and Memory at MIT observed how nascent neurons struggle to reach their rightful places in a sophisticated human brain network model of Rett syndrome, yielding new insights into how developmental deficits are observed in humans. patient’s brain. with devastating interference may arise. Rett syndrome, which is characterized by symptoms including severe intellectual disability and impaired social behavior, is caused by a mutation in the MECP2 gene. To gain new insight into how mutations affect the early stages of human brain development, researchers in the lab of Mriganka Sur, Newton Professor of Neuroscience in MIT’s Department of Brain and Cognitive Sciences, grew 3D cell cultures called cerebral organoids, or miniature brains, using cells from humans. -people with the MECP2 mutati

China successfully launches Wentian lab module, adds a second part to its three-module space station

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China launched the Wentian lab module for the space station. Photo: Fan Wei/GT Wentian lab module successfully launched. Graphics: GT After moving into the core module of China’s Tianhe space station for more than a month, the crew of three Shenzhou-14 taikonauts are now just hours away from carrying out their first major mission in orbit, accepting the arrival of the Wentian laboratory module and adding it to the China Space Station three modules. With coconut palms shaking on the coastline of the tropical island province of Hainan in South China, the giant Long March-5B Y3 heavy-lift rocket lifted off from the Wenchang Space Launch Site at 2:22 p.m., and successfully delivered Wentian – the first lab module for the station. the country’s outer space – to a predetermined orbit. After a flight of about eight minutes, the Wentian module separated from the rocket body and entered its designated orbit, marking the success of the launch mission, China’s Manned Space Agency said in a sta