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PD-1 dependent NK cell regulation of CD8 + T-cells. C57BL/6 mice were infected with an adenoviral vector encoding the HBV genome and treated with anti-NK1.1 (⍺NK) or isotype control antibodies prior to therapeutic vaccination. Intrahepatic lymphocytes were harvested 14 days after immunization. (A) Quantitative real-time PCR analysis of HBsAg mRNA extracted from the liver of infected mice. (B) Representative plot of CD8 + T-cells isolated from the spleen of CD45.2 PD-1KO or CD45.1 wild-type (WT) mice were transferred to recipients of opposite congenic mice one day before therapeutic vaccination. Examples of PD-1 and IFN . expressions you production in transferred PD-1KO and WT CD8+ T cells. *, pScience Translational Medicine (2022). DOI: 10.1126/scitranslmed.abi4670 Scientists have found that the body’s own natural killer cells can suppress the immune benefits of therapeutic vaccines, a problem that can predispose to inoculation against ch

Triptans, a class of commonly prescribed migraine medications, may also be useful in treating obesity, according to a new study by scientists at UT Southwestern. In a study in obese mice, a daily dose of a triptan caused the animals to eat less and lose weight for a month, the team reported in the Journal of Experimental Medicine. “We have shown that there is real potential for reusing these drugs, which are already known to be safe, for appetite suppression and weight loss,” said study leader Chen Liu, Ph.D., Assistant Professor of Internal Medicine and Neuroscience and an investigator at the Peter O’Donnell Jr. Brain Institute. Obesity affects more than 41% of all adults in the US and increases the risk of heart disease, stroke, diabetes, and certain types of cancer. Most treatments for obesity focus on eating habits and physical activity. Scientists have long known that serotonin, a chemical messenger found throughout the brain and body, plays a key role in appetite. However, the