Vly News - Professional news Platform

Immunotherapy, such as immune checkpoint inhibitors, has changed the treatment of advanced cancers. Unlike chemotherapy which kills cancer cells, these drugs help the immune system to find and destroy the cancer cells themselves. Unfortunately, only a subset of patients respond to immune checkpoint inhibitors in the long term; and these treatments can be expensive and with side effects. Researchers have developed a two-step approach using whole-exome sequencing to target genes and pathways that predict whether cancer patients will respond to immunotherapy. Studies published in Nature Communication and conducted by researchers at New York University, Weill Cornell Medicine, and the New York Genome Center, illustrates how using whole-exome sequencing can better predict treatment response than current laboratory tests. “Can we better predict who will benefit from immunotherapy? Scientists have developed a variety of biomarkers that help anticipate immunotherapy treatment responses, b

The human genome is littered with “selfish genetic elements”, which do not appear to benefit the host, but only seek to reproduce. Selfish genetic elements can wreak havoc by, for example, distorting sex ratios, impairing fertility, causing dangerous mutations, and potentially even causing population extinction. Biologists at the University of Rochester, including Amanda Larracuente, professor of biology, and Daven Presgraves, University Dean’s Professor of Biology, are using population genomics for the first time to explain the evolution and consequences of known selfish genetic elements. as Segregation Distortion ( SD ). In a paper published in the journal eLife the researchers reported that SD has led to dramatic changes in chromosomal organization and genetic diversity. Sequencing the genome first Researchers use fruit flies as model organisms to study SD , a selfish genetic element that deviates from the rules of just genetic transmission. Fruit flies share about 70 percent of