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A set of genes that promote the sensation of sweetness are also important for protein management during fly development, according to a new study led by the University of Bristol and colleagues, published today (July 21) in the open access journal PLOS Biology. These findings broaden the understanding of key processes in successful development and suggest a link between taste-related genes and impaired protein aggregation. Protein homeostasis or proteostasis, is a set of processes that maintains cellular proteins in a functional state and removes damaged proteins that cannot be repaired. Ribosomes are multi-protein molecular machinery that synthesizes proteins and mutations in genes encoding ribosomal proteins not only impair protein synthesis but also impair proteostasis, leading to chronic proteotoxic stress. That stress, in turn, has a number of cellular consequences and results in delayed development and other irregularities. To better understand the disturbances caused by such

A set of genes that promote the sensation of sweetness are also important for protein management during fly development, according to a new study by Eugenia Piddini of the University of Bristol, UK, and colleagues, published July 21. st in open access journal PLOS Biology . These findings broaden the understanding of key processes in successful development, and demonstrate a link between taste-related genes and impaired protein aggregation. Protein homeostasis, or proteostasis, is a set of processes that maintain cellular proteins in a functional state, and remove damaged proteins that cannot be repaired. Ribosomes are multi-protein molecular machinery that synthesizes proteins, and mutations in the genes encoding ribosomal proteins not only impair protein synthesis but also impair proteostasis, leading to chronic proteotoxic stress. That stress, in turn, has a number of cellular consequences and results in delayed development and other irregularities. To better understand the distu

Local opposition to the plan has so far been successful, with one planning application now making its way to the Supreme Court after being rejected by the council and the Victorian Civil and Administrative Court. An application for 16 residences at 21-27 George Street was rejected at the VCAT last month due to concerns about conflicts between the horse and housing industries. “[It] is a form of intense housing development that will be sandwiched between existing equine activity,” the VCAT decision said. “I’m afraid the proposal will allow … adverse effects on residential comfort from noise, smell and visual impact.” Horse trainer Ian Stewart at his stable on George Street in Kilmore where the developers bought the land. Credit: Edde Jim On the other side of George Street, a separate application for 20 residences was submitted by the same developer last month. The plan has not yet gone to the council, but is also expected to be rejected. Kilmore rate-paying association president Vyvien