Mortality and Changes in Deep Vein Thrombosis Prevalence Associated with the SARS-CoV-2 P.1 variant
Background and purpose Thrombosis is one of the significant challenges associated with cardiovascular disease and the leading cause of death globally. This study aims to determine the monthly and overall mortality rates by sex and age group in hospitalized patients with coronavirus disease 2019 (COVID-19) and the prevalence of deep vein thrombosis (DVT) in these patients. We also investigated whether the P.1 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects DVT. Method We determined the overall prevalence of COVID-19 per gender, age, and monthly mortality using hospital data at the São José do Rio Preto School of Medicine, state of São Paulo, Brazil. Data of COVID-19 patients with DVT as determined by echo-Doppler ultrasound (EDU) were analyzed considering two time periods (before and after the onset of the predominance of the SARS-CoV-2 P. Patients with COVID-19 but without DVT comprised the control group. The first period is from March 2020 to Febru