Investigational Drug Promotes Nerve Repair After Injury - Neuroscience News
Summary: An experimental drug penetrating the brain is in development as a cancer treatment could promote regeneration of nerves damaged after spinal cord injury, researchers report. Source: University of Birmingham Scientists from the University of Birmingham have shown that a prospective brain-penetrating drug currently being developed as a cancer therapy could promote regeneration of nerves damaged after spinal trauma. The study, published today in Clinical Medicine and Translation used cell and animal models to demonstrate that when taken by mouth the drug candidate, known as AZD1390, can block the response to DNA damage in nerve cells and promote regeneration of damaged nerves, thereby restoring sensory and motor function after spinal cord injury. The announcement comes weeks after the same research team showed a different investigative drug (AZD1236) could reduce damage after spinal cord injury, by blocking the inflammatory response. Both studies were supported by the AstraZene