Nano Pom-Pom: A New Method for Detecting Cancer Biomarkers
Nano-sized extracellular vesicle (EV) exosomes serve as a reliable source of biomarkers. However, identification of cancer biomarkers through mapping of exosomal multi-omic molecular information is challenging due to the heterogeneous population of exosomes derived from diverse cell types. Study: Nano pom-pom prepared exosomes allow detection of highly specific cancer biomarkers. Image Credit: Meletios Verras/Shutterstock.com In an article published in the journal Communication Biology , the researchers introduced new three-dimensional (3D) nanographene immunomagnetic particles for specific capture and release (defined by markers) from intact exosomes. The newly designed 3D structured nanographene particles have a unique pom-pom flower morphology. In addition, the capture and release of intact exosomes is carried out via photo-click chemistry. This exosome isolation approach allows the identification of cancer biomarkers with enhanced sensitivity and specificity. Multi-omic exosom