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image: Sound reduces pain in mice by decreasing the activity of neurons in the brain’s auditory cortex (green and magenta) that project to the thalamus. see again Credit: Wenjie Zhou An international team of scientists have identified a neural mechanism through which sound dulls pain in mice. The findings, which could inform the development of safer methods for treating pain, are published in Science . The study was led by researchers at the National Institute of Dental and Craniofacial Research (NIDCR); China University of Science and Technology, Hefei; and Anhui Medical University, Hefei, China. NIDCR is part of the National Institutes of Health. “We needed more effective methods to manage acute and chronic pain, and that started with gaining a better understanding of the basic neural processes that regulate pain,” said NIDCR Director Rena D’Souza, DDS, Ph.D. “By uncovering the circuits that mediate the pa...

A team led by the University of Minnesota Twin Cities has developed a new technique to image mRNA molecules in the brains of live mice. By genetically modifying the mice to produce mRNA labeled with the green fluorescent protein (shown above), the researchers were able to see when and where the mouse brain produced Arc mRNA. Credit: Hye Yoon Park, University of Minnesota’s Twin Cities A team led by the University of Minnesota’s Twin Cities has developed a new technique that allows scientists and engineers, for the first time, to visualize mRNA molecules in the brains of living mice. This research reveals new insights into how memories are formed and stored in the brain and could provide scientists with new information about diseases like Alzheimer’s. This paper was published in Proceedings of the National Academy of Sciences (PNAS) . There are still many mysteries surrounding the ...

A team led by the University of Minnesota’s Twin Cities has developed a new technique that allows scientists and engineers, for the first time, to visualize mRNA molecules in the brains of living mice. This research reveals new insights into how memories are formed and stored in the brain and could provide scientists with new information about diseases like Alzheimer’s. The paper is published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS), a peer-reviewed, multidisciplinary, high-impact scientific journal. There are still many mysteries surrounding the process of how memories are physically created and stored in the brain. It is well known that mRNA—a type of RNA involved in making proteins—is produced during the processes of memory formation and storage, but the technology for studying this process at the cellular level is still limited. Previous research has often involved dissecting mice to examine their brains. A research...