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Jason Ryan was enjoying a cold beer in Fiji when All Blacks coach Ian Foster called and asked if he wanted to jump into the rugby furnace. A few days after Foster asked him to put steel into the All Blacks pack after John Plumtree was sacked, Ryan stepped down as front coach of the Crusaders and the Fiji national team. Ryan, who has been in Fiji for the Pacific Nations Cup, said he must seize a golden opportunity to help the All Blacks turn their fortunes around after a 2-1 draw to Ireland. Ella Bates-Hermans/Stuff Jason Ryan joined the All Blacks coaching staff after John Plumtree was sacked. But he also had to break the news to his good friend and Crusader boss Scott Robertson, the man who had helped tie the rocket to Ryan’s coaching career. Yes, Ryan said, it was a difficult conversation at first, but he received Robertson’s blessing: “I am a loyal person. I really care,” Ryan said. “He’s done a lot for me. But… he’s really bee...

Using the UT Southwestern Cryo-Electron Microscopy Facility, researchers have for the first time captured images of autoantibodies bound to nerve cell surface receptors, revealing the physical mechanisms behind neurological autoimmune disease. The findings, published in Cell, could lead to new ways to diagnose and treat autoimmune conditions, the study authors said. “We are entering a new era of understanding how autoimmune diseases work in the central nervous system,” says Colleen M. Noviello, Ph.D., Assistant Professor of Neuroscience at UTSW who specializes in obtaining cryo-electron microscopy (cryo-EM). ) images up to atomic resolution. Dr. Noviello led the research with Ryan Hibbs, Ph.D., Associate Professor of Neuroscience and Biophysics, Effie Marie Cain Scholar in Medical Research, and Investigator Peter O’Donnell Jr. Brain Institute and Harald Prüss of the Universitätsmedizin Berlin. Researchers have studied autoimmune diseases — a class of conditions in which the i...

picture: Autoimmune encephalitis occurs when antibodies or T cells go bad and attack the brain. In this study, UTSW researchers and colleagues from Berlin used cryo-electron microscopy to determine the atomic structure of autoantibodies bound to GABAA receptors. The receptor is an important protein in the brain and a target in autoimmune encephalitis. see again Credit: UT Southwestern Medical Center *Click here to watch the video Using the UT Southwestern Cryo-Electron Microscopy Facility, researchers have for the first time captured images of autoantibodies bound to nerve cell surface receptors, revealing the physical mechanisms behind neurological autoimmune disease. His findings, published in Cell, could lead to new ways to diagnose and treat autoimmune conditions, the study authors said. “We are entering a new era of understanding how autoimmune diseases work in the central nervous system,” says Colleen M. Noviello, Ph.D.,...