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Exposure to copper in the environment and alpha-synuclein protein in the human brain may play an important role in the pathogenesis of Parkinson’s disease. The researchers were able to show how the protein takes on an unusual shape when exposed to large amounts of copper ions. These findings could help develop new strategies for the treatment of neurodegenerative diseases. The causes of Parkinson’s disease are not fully understood. Long before the onset of characteristic muscle tremors, the appearance of faulty proteins in the brain can be the first sign. Researchers at Empa and the University of Limerick in Ireland have now taken a closer look at the abnormal shape of these alpha-synucleins in the form of a protein ring. By doing so, they were also able to visualize at the nanoscale the relationship with environmental pollution by copper. It highlights the development of neurodegenerative diseases and the role of biometals in the disease pro

Washington [US], July 9 (ANI): Exposure to copper in the environment and the protein alpha-synuclein in the human brain may play an important role in the pathogenesis of Parkinson’s disease. The researchers were able to show how the protein takes on an unusual shape when exposed to large amounts of copper ions. These findings could help develop new strategies for the treatment of neurodegenerative diseases. The causes of Parkinson’s disease are not fully understood. Long before the onset of characteristic muscle tremors, the appearance of faulty proteins in the brain can be the first sign. Researchers at Empa and the University of Limerick in Ireland have now taken a closer look at the abnormal shape of these alpha-synucleins in the form of a protein ring. By doing so, they were also able to visualize at the nanoscale the relationship with environmental pollution by copper. It highlights the development of neurodegenerative diseases and the role of biometals in the disease proces