Vly News - Professional news Platform

Macrophages are key cells of our innate immune response. By filling up almost all the tissues in our body, these cells have an important role in keeping our organs in a healthy state, as they are constantly removing dead cells or eliminating microbes invading tissues. As cells that specialize in eating and devouring, macrophages are very well adapted to take in, digest, and destroy foreign materials. However, certain microorganisms and bacteria such as Salmonella have developed strategies to protect themselves from ingesting macrophages, causing severe typhoid infection and inflammation. Scientists from the MPI of Immunobiology and Epigenetics in Freiburg now report in their latest study published in the scientific journal Natural Metabolism how inter-organelle crosstalk between phago-lysosomes and mitochondria limits the growth of these bacteria in macrophages. Signals from digestive cell organelles The interior of a macrophage, like most other cells, is divided into different com...

Chris Blumas understands why investors might be nervous about a looming recession. Illustration after illustration of Joel Kimmel Money manager Chris Blumas understands why many investors are reluctant to buy stocks at this time, given the economic threats, including predictions of a growing recession. But in his view, the market is currently much less risky as valuations for many securities have dropped significantly, meaning the potential for better returns is even higher for investors holding funds for the long term. “That’s not to say that things can’t go down in the short term, but for anyone with a time horizon of more than three to five years, now is a pretty interesting time to invest if you can look beyond short term volatility. , said Mr. Blumas, a Toronto-based portfolio manager at Raymond James Investment Counsel Ltd., a multi-manager platform with approximately $1 billion in assets under management. “I see a lot of value in the market today,” added...

CAMBRIDGE, MA – Receptors found on the surface of cells bind to hormones, proteins, and other molecules, helping cells respond to their environment. MIT chemists have now discovered how one of these receptors changes its shape when it binds to its target, and how that change triggers cells to grow and reproduce. This receptor, known as the epidermal growth factor receptor (EGFR), is overexpressed in many cancers and is the target of several cancer drugs. These drugs often work well at first, but tumors can become resistant to them. Better understanding the mechanism of these receptors could help researchers design drugs that can circumvent that resistance, said Gabriela Schlau-Cohen, a professor of chemistry at MIT. “Thinking about more general mechanisms for targeting EGFR is an exciting new direction, and gives you new avenues for thinking about possible therapies that may not develop resistance easily,” he said. Schlau-Cohen and Bin Zhang, Pfizer-Laubach Assistant Prof...