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Showing posts with the label University of California

The elusive particle: Scientists embark on a quest to find dark matter

In a former gold mine a mile underground, inside a titanium tank filled with a rare liquefied gas, scientists have begun a search for what so far has not been able to find: dark matter. Scientists are pretty sure invisible objects make up most of the mass of the universe and say we wouldn’t be here without them – but they don’t know what they are. The race to solve this great mystery has taken one team to the depths beneath Lead, South Dakota. The question for scientists is basic, says Kevin Lesko, a physicist at Lawrence Berkeley National Laboratory. “What is this great place I live in? Right now, 95% of it is a mystery.” The idea is that a mile of dirt and rock, a giant tank, a second tank, and the world’s purest titanium will block out nearly all of the cosmic rays and particles that glide around – and penetrate – all of us every day. But dark matter particles, scientists say, can avoid all those obstacles. They hoped someone wo...

Scientists Map Network of Disease-Related Immune Genes

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“These results help us refine a systematic network map that can serve as an instruction manual on how human immune cells function and how we can engineer them to our advantage,” said Alex Marson MD, PhD, director of the Gladstone-UCSF Institute of Genomic Immunology and senior author of the new study, published in Natural Genetics . The study, which was carried out in collaboration with Jonathan Pritchard PhD, professor of genetics and biology at Stanford School of Medicine, is also important for better understanding how variations in a person’s genes are related to the risk of autoimmune diseases. Immunity Insights from CRISPR Researchers know that when the immune system’s T cells—white blood cells that can fight infection and cancer—become active, the levels of thousands of proteins in the cells change. They also know that many proteins are interconnected so that a change in the level of one protein can cause a change in the level of another. Scientists repres...