When friendly forces become enemies: Scientists blunt the impact of natural killer cells to increase vaccine effectiveness
PD-1 dependent NK cell regulation of CD8 + T-cells. C57BL/6 mice were infected with an adenoviral vector encoding the HBV genome and treated with anti-NK1.1 (⍺NK) or isotype control antibodies prior to therapeutic vaccination. Intrahepatic lymphocytes were harvested 14 days after immunization. (A) Quantitative real-time PCR analysis of HBsAg mRNA extracted from the liver of infected mice. (B) Representative plot of CD8 + T-cells isolated from the spleen of CD45.2 PD-1KO or CD45.1 wild-type (WT) mice were transferred to recipients of opposite congenic mice one day before therapeutic vaccination. Examples of PD-1 and IFN . expressions you production in transferred PD-1KO and WT CD8+ T cells. *, pScience Translational Medicine (2022). DOI: 10.1126/scitranslmed.abi4670 Scientists have found that the body’s own natural killer cells can suppress the immune benefits of therapeutic vaccines, a problem that can predispose to inoculation against ch