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Summary: An experimental drug penetrating the brain is in development as a cancer treatment could promote regeneration of nerves damaged after spinal cord injury, researchers report. Source: University of Birmingham Scientists from the University of Birmingham have shown that a prospective brain-penetrating drug currently being developed as a cancer therapy could promote regeneration of nerves damaged after spinal trauma. The study, published today in Clinical Medicine and Translation used cell and animal models to demonstrate that when taken by mouth the drug candidate, known as AZD1390, can block the response to DNA damage in nerve cells and promote regeneration of damaged nerves, thereby restoring sensory and motor function after spinal cord injury. The announcement comes weeks after the same research team showed a different investigative drug (AZD1236) could reduce damage after spinal cord injury, by blocking the inflammatory response. Both studies were supported by the AstraZene...

Washington [US]July 10 (ANI): Researchers have definitively linked the function of a protein-specific domain important in plant microbial biology to cancer triggers in humans, knowledge that has eluded scientists for decades. The team’s findings, published in Nature Communications Biology, open new avenues for the development of selective drug therapies to fight different types of cancers such as cancers that start in the breast and stomach. Read Also | Women With Anorexia Likely To Have Underweight Babies, Study Says. ORNL scientists set out to experimentally prove what they first concluded with computational studies: that the plasminogen-apple-nematode domain, or PAN, is associated with cell proliferation that promotes tumor growth in humans and defense signaling during plant-microbial interactions in bioenergetic plants. This association was first made when researchers were exploring the genomes of plants such as poplars and willows. In the latest study, the ORNL team demonst...