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New research from the University of Cincinnati is showing early indications that light could be used as a treatment for certain ailments, including cancer. Researchers from UC, University of Illinois Urbana-Champaign and University at Buffalo published the results of their study showing light-activated proteins can help normalize dysfunction in cells in the journal. Nature Communication July 25. Research findings Research centers on the function of mitochondria, the organelles in cells that act as the cell’s “power generator” and source of energy. Organelles are small specialized structures that perform various jobs in the cell. Jiajie Diao, PhD, one of the study’s authors, says hundreds of mitochondria are constantly coming together (a process called fusion) and dividing into smaller pieces (a process called fission) to keep them in balance in healthy cells. But when mitochondria don’t function properly, an imbalance of these fission and fusion processe...

Among those developers are China Evergrande, the world’s most indebted property developer, with about US$300 billion ($430 billion) in liabilities, and the company that defaulted on its foreign bonds last year bringing home the scale of the crisis in China’s property sector. Its suppliers want to be held accountable for their loans, which may be problematic given that the group has not yet developed a workable restructuring plan and risks being declared default on its domestic bonds by domestic investors who have, until now, been prepared to extend the grace period. Evergrande has until the end of this month to work out its plans and prevent what would become a landmark default in China. Borrowers for incomplete apartment developments in China refuse to pay their debts, exacerbating the existing crisis in China’s vital property sector. Credit: Bloomberg Its ability to meet that deadline was complicated by the forced resignations of its chief executive and chief financi...

When Rob Gibbs started volunteering as a firefighter at the CFA, he was strong both physically and mentally, but 21 years later he’s sitting on the couch at his Cowwarr home feeling like a burden to his family. Key points: Rob Gibbs was diagnosed with chronic myeloid leukemia in 2016 He fought the fire for 15 years and urged firefighters to have regular blood tests The World Health Organization says firefighting is a cancer-causing profession Mr Gibbs, 52, was diagnosed with chronic myeloid leukemia in 2016, had one of his legs amputated, and has spent about three of the last five years in hospital. “It’s hard with everything going on with my body. Sometimes you think, why bother?” he says. “If it weren’t for my wife and daughter, I might have left a while ago in all honesty.” Importance of PPE Mr Gibbs has been fighting fires in Gippsland and in metropolitan Melbourne for 15 years and is now encouraging working firefighters to protect themselv...

For some children, birthdays are very valuable to celebrate. Jessica Gowers can’t tell you whether her son Riley will make it to the age of 13, 18, or 21. He didn’t think they would see his seventh birthday in March. But, they did. Riley was born with CHARGE syndrome, a complex set of medical problems. Riley with Toy Story cake. ( Provided: Jessica Gowers ) Apart from heart problems, he was deaf, mute, and partially blind. “Riley was born in 2015, we were in the hospital for 11 months. 2016, six months, 2017, six months, 2018, dodging bullets. 2019, four months,” Ms Gowers said. With all the time in the hospital, it’s no wonder Miss Gowers doesn’t have time to bake. Or many other things for that matter. So he called Cake Angels, a team of 2,100 professional decorators across the country who donate incredible custom cakes to children with lifelong or life-limiting conditions. This is not your average banana cake with cream cheese icing. Cakes worth u...

Stuttgart – A team of scientists in the Department of Physical Intelligence at the Max Planck Institute for Intelligent Systems has combined robotics with biology by equipping E. coli bacteria with artificial components to build a biohybrid microrobot. First, as can be seen in Figure 1, the team attached several nanoliposomes to each bacterium. In its outer ring, this spherical carrier encloses a material (ICG, green particle) that melts when illuminated by near infrared light. Further to the center, within the aqueous core, liposomes encapsulate water-soluble chemotherapeutic drug (DOX) molecules. The second component the researchers attached to the bacteria were magnetic nanoparticles. When exposed to a magnetic field, the iron oxide particles serve as a boost over these already highly motile microorganisms. In this way, it is easier to control the bacterial pool – a design refined towards in vivo applications. Meanwhile, the binding strap of liposomes and magnetic particles in...

Nano-sized extracellular vesicle (EV) exosomes serve as a reliable source of biomarkers. However, identification of cancer biomarkers through mapping of exosomal multi-omic molecular information is challenging due to the heterogeneous population of exosomes derived from diverse cell types. Study: Nano pom-pom prepared exosomes allow detection of highly specific cancer biomarkers. Image Credit: Meletios Verras/Shutterstock.com In an article published in the journal Communication Biology , the researchers introduced new three-dimensional (3D) nanographene immunomagnetic particles for specific capture and release (defined by markers) from intact exosomes. The newly designed 3D structured nanographene particles have a unique pom-pom flower morphology. In addition, the capture and release of intact exosomes is carried out via photo-click chemistry. This exosome isolation approach allows the identification of cancer biomarkers with enhanced sensitivity and specificity. Multi-omic exosom...

As part of a series of cycles of loss, supported by a philanthropic grant from the Paul Ramsay Foundation, we published three articles on the social determinants of health. They looked at how factors such as your income, where you live, and your background influence your risk of cancer, dementia and heart disease. In Australia, the odds of living for at least five years after being diagnosed with cancer have increased from 51% to 70% over the past 30 years. But not everyone has the same opportunities. Likewise, your risk of developing cancer differs depending on where you live, how wealthy you are, and your parents’ wealth and social situation. How does your socioeconomic group affect your cancer risk? If you live in a socially disadvantaged area – defined by the low salaries of a largely unskilled workforce, high unemployment, and low levels of education – you have a 5% higher chance of developing cancer than those living in an area that most benefited. Your survival also tend...

Southampton [UK]July 10 (ANI): In the fight against Cancer, new insights into the key properties of antibodies have been discovered by researchers at the University of Southampton. The interdisciplinary study, published in Science Immunology, reveals how changing the flexibility of antibodies can stimulate a stronger immune response. Read Also | Guru Purnima 2022 Date and Time in India: Know Tithi, Its Customs and Importance of Celebrating the Birthday of the Great Vedic Saint Vyasa. These findings enabled the Southampton team to design antibodies to activate important receptors on immune cells to “turn them on” and provide a more potent anti-cancer effect. The scientists believe their findings could pave the way for improving antibody drugs that target cancer as well as other autoimmune diseases. Read Also | 2022 Wimbledon Final: Novak Djokovic Lifts 21st Grand Slam Title. In the study, the team investigated antibody drugs that target the CD40 receptor for cancer treatmen...

The researchers definitively linked the function of a protein-specific domain important in plant microbial biology to cancer triggers in humans, knowledge that scientists have avoided for decades. Team findings, published in natural Communication Biology, opens new avenues for the development of selective drug therapies to fight various types of cancer, such as cancers that start in the breast and stomach. ORNL scientists set out to experimentally prove what they first concluded with a computational study: that the plasminogen-apple-nematode, or PAN, domain is associated with cell proliferation that promotes tumor growth in humans and defense signaling during plant-microbial interactions in plant-bioenergy. plant. This association was first made when researchers were exploring the genomes of plants such as poplars and willows. Read also: Cancer drug that could potentially treat muscular dystrophy In the latest study, the ORNL team demonstrate...

Washington [US]July 10 (ANI): Researchers have definitively linked the function of a protein-specific domain important in plant microbial biology to cancer triggers in humans, knowledge that has eluded scientists for decades. The team’s findings, published in Nature Communications Biology, open new avenues for the development of selective drug therapies to fight different types of cancers such as cancers that start in the breast and stomach. Read Also | Women With Anorexia Likely To Have Underweight Babies, Study Says. ORNL scientists set out to experimentally prove what they first concluded with computational studies: that the plasminogen-apple-nematode domain, or PAN, is associated with cell proliferation that promotes tumor growth in humans and defense signaling during plant-microbial interactions in bioenergetic plants. This association was first made when researchers were exploring the genomes of plants such as poplars and willows. In the latest study, the ORNL team demonst...

When Shelley Bishop was diagnosed with Hodgkin’s lymphoma earlier this year, the first person she contacted was her friend Delta Goodrem, who was treated for blood cancer as a teenager. With no history of cancer in her family, Ms Bishop sought the advice of someone with life experience with the disease to calm her fears. “For me, it was the unknown, it was very scary,” Bishop said. Shelley Bishop received words of support from Delta Goodrem. ( Provided: Shelley Bishop ) “I panicked for the first few weeks when I was diagnosed. I panicked. “Delta is basically just saying: ‘This is really scary, but there’s nothing you can’t afford. You just have to take one small step every day to get stronger and listen to your body. Take your time and rest when you need to. Don’t try and push yourself too hard.’ “He literally based the whole experience on me. I have no doubt that he was put in my path for a reason.” Bishop and the...